Spinal Botox Jab Relieves Inflammation Pain

Botulinum A (a neurotoxin protein produced by the bacillus Clostridium Botulinum) or Botox has been seen to relieve pain and act as an analgesic. Botox is best known as the wonder substance that when injected in specific regions can paralyze certain muscles and thus prevent wrinkles.

Besides, erasing away wrinkles to make your face look more youthful, botox is now being envisaged as an effective medication against inflammation and pain. Earlier, botox is known to have reduced symptoms of several disorders that affect muscles.

Experiments on mice and analyses of the findings at the Seoul National University indicate that Botox can reduce response to inflammation and act as an analgesic. The research was headed by Won-Ho Lee. The findings of the research study were published in January, in the journal “Anesthesia and Analgesia”, the official publication of the IARS (International Anesthesia Research Society).

The Botox extract was injected into the spinal canal (intrathecal) of the mice. Further, the experiments also showed that the pain reducing action of Botox did not leave behind any adverse reaction or side effect in the mice selected for the experiment.

How the experiment was conducted

  • A chemical was injected in the paw of mice
  • There was predictable two-phase pain response from the mice due to the injection
  • Some mice received the Botulinum neurotoxin fluid while some did not
  • For four weeks, the behavior of all mice were monitored
  • For every single spinal injection of Botulinum, a pain reducing effect was evident
  • The mice that received the neurotoxin injections displayed lesser pain behavior as compared to those mice that did not
  • Also, there were no abnormalities reported in the spinal area nor any adverse effects of the spinal injection, indicating that the pain reducing Botulinum did not have side effects that could deter normal spinal functioning
  • It was seen that the peak effect of the injection was after 10 days of administration and the effect reduced after two weeks

Botox is an extremely popular cosmetic solution for ageing problems of the skin. When the substance successfully reduced symptoms of other health problems like neck dystonia, uncontrolled eye blinking, cephalgia headaches and so on, it was attributed to Botox’s ability to paralyze muscles.

However, the recent experiment has indicated that the substance could probably act as an analgesic too. The experiments showed that the pain reducing effect though obvious, is temporary and wears off after some time has elapsed.

Further research studies along these lines can lead to

  • Awareness of the exact mechanism of pain control by Botulinum; this can lead to more effective administration of the substance
  • Indication of the analgesic effect of Botox in humans and how it can be used to treat chronic pain conditions
  • Therapeutic options to free future generations chronic pain can be explored, according to the Editor-in-Chief of “Anesthesia and Analgesia”, Dr. Steven Shafer



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